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All these clinical safety data are consistent with the published Leiter II 24-month follow-up study data and support that Jintrolong® can increase convenience and compliance in GHD children without increasing safety concerns.
To further evaluate the clinical safety of Jintrolong®, especially for possible CP-related adverse reactions, pediatric GHD Phase III (360 patients) and L IV (3,000 patients) studies with 26 weeks of treatment were analyzed, and a follow-up study of Phase IV with treatment time as long as 3 years welches also conducted, comparing the incidence of adverse events following long-term Jintrolong® or daily rhGH treatment. The combination of nonclinical and clinical studies described hinein this report details the comprehensive safety profile of Jintrolong®.
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The dose might require adjustment individually for human GH replacement therapy. Please follow your physicians instructions.
hinein the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.
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kilometer is the Michaelis constant, and Vmax is the maximum Satz of elimination of the nonlinear pathway. Vc is the volume of distribution of the central compartment. F stands for bioavailability.
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Due to the administration time and dose difference between cynomolgus monkeys and humans, we must generate cannabis apotheke günstige preise a pharmacokinetic (PK) model to bridge the preclinical and clinical studies. Serial blood samples were collected from animals up to 8,736 h postdose for evaluating the PK of PEG-rhGH.